No. EES 2.2 or later, no longer needs an EES License and thus no longer needs to be activated.
EES 2.0 required an EES license. If you install EES 2.0 and then immediately upgrade to 2.0 SP4 or later you no longer need to activate and un-activated EES.
EES 2.2 or later no longer has an Red ball Activation command as it is no longer required.